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HAART

Heart
Picmonic
HAART stands for highly-active antiretroviral therapy. This medication regimen is used for patients who display with AIDS defining lesions, or have CD4+ counts below 350 internationally, or below 500 in the United States. This regimen can be summarized by knowing the patient will take 2 NRTI medications + 1 of the following: an NNRTI, a protease inhibitor or an integrase inhibitor.
7 KEY FACTS
HIV
Band-AIDS

HAART is a medication protocol for treating patients with HIV who have AIDS-defining lesions, or low CD4+ levels.

Begin at Diagnosis
Diagnostic-computer

Once the diagnosis of HIV is made, HAART can be initiated. Antiretroviral therapy is recommended for all HIV-infected individuals to reduce the risk of disease progression. It is also is recommended for HIV-infected individuals for the prevention of transmission of HIV.

3 Drugs
(3) Tree with Drugs

This treatment regimen consists of 3 drugs. A multiple drug approach is used to help attack the HIV virus at varying points of its life cycle and replication, and to resist mutation.

2 NRTIs (Nucleoside Reverse Transcriptase Inhibitors)
(2) Tutu Nerd-ties

HAART is initiated with treatment of 2 NRTI medications. These 2 drugs are then combined with a third medication. NRTI medications work by inhibiting binding of nucleotides to reverse transcriptase and by terminating the DNA chain.

AND ONE OF THE FOLLOWING:
NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitor)
Nun-Nerd-tie

The third drug used in HAART can be an NNRTI, which is a drug that treats HIV by inhibiting nucleotide binding to reverse transcriptase at a different site of action than NRTIs.

or Protease Inhibitor
Propeller-ace with Inhibiting-chains

The third drug used in HAART can be a protease inhibitor. This drug works by preventing the maturation of the new HIV virus from within the host cell.

or Integrase Inhibitor
Integra with Inhibiting-chains

The third medication used in HAART, along with the NRTIs, can be an integrase inhibitor. Medications in this class work by inhibiting HIV genome integration into the host cell.

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