Master Doxorubicin (Adriamycin) with Picmonic for Medicine

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Doxorubicin (Adriamycin)

Dachshund-rubix-cube
Picmonic
Doxorubicin, or adriamycin, is an anthracycline antibiotic used in cancer therapy. It works by intercalating DNA, preventing new cell growth in tumors, but leads to heart damage. This cardiotoxic side effect can be decreased with dexrazoxane administration.
7 KEY FACTS
INDICATIONS
Solid Tumors
Tumor-guy

Doxorubicin is used to treat solid tumors; meaning it is useful against cancers of the bladder, breast, stomach, ovaries, lungs, thyroids, and soft-tissue sarcomas.

Lymphomas and Leukemias
Lime-foam and Leukemia-Luke

This drug is used most commonly to treat leukemias and Hodgkin's lymphoma.

MECHANISM
Free Radical Production
Free Radicals

Doxorubicin increases free radical production in tumor cells, leading to cytotoxicity.

Intercalates DNA
Inner-cleats DNA

This medication inhibits biosynthesis of new cells, as it intercalates DNA. Once topoisomerase has split the DNA to be replicated, doxorubicin intercalates the DNA (gets in between the two DNA strands), preventing the double helix from being resealed. Thus, it stops the process of replication.

Prevents Double Helix from Sealing
Preventing the Double Helix from Closing

After the DNA double helix is split, Doxorubicin intercalates the two strands. This mechanical obstruction prevents the DNA double helix from resealing.

SIDE EFFECT
Cardiotoxicity
Heart with Toxic-green-glow

Doxorubicin is a cardiotoxic drug, and it can lead to congestive heart failure. Mechanisms for how this dose-dependant toxicity occurs include myocardial apoptosis, downregulation of contractile proteins and oxidative stress on myocardial cells.

Dexrazoxane Decreases Toxicity
Desk-red-socks-fan removing Toxic-green-glow

Dexrazoxane is a cardioprotective agent used to protect the heart from chemotherapeutic drugs, like doxorubicin. It works by chelating iron ions, decreasing the amount of superoxide radicals that can harm the heart.

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