Master Celecoxib with Picmonic for Medicine

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Celecoxib

Celery-costume
Picmonic
This is a COX-2-selective NSAID that lacks many of the toxic GI effects of other NSAIDS that have COX-1 inhibitory affects in addition to COX-2. This was a source of much promise initially; however, Celecoxib has been found to increase the risk of thrombosis possibly due to decreased prostacyclin production causing platelet aggregation.
9 KEY FACTS
INDICATIONS
Rheumatoid Arthritis
Roman King-Arthur

Celecoxib can be used in rheumatoid arthritis, as it is helpful in patients who need regular and long-term pain relief.

Osteoarthritis
Ostrich-King-Arthur

Celecoxib is indicated for use in osteoarthritis, as it has less side effects than other NSAIDs.

Pain
Pain-bolt

Celecoxib relieves pain via inhibition of COX-2.

MECHANISM OF ACTION
NSAID
N-sad

Celecoxib is an NSAID; however, unlike most other NSAIDs it selectively blocks COX-2 and has little effect on COX-1.

Selectively Inhibits COX-2
Selectively puts Inhibiting-chains on Cock in (2) Tutu only

Due to it’s selective inhibition of COX-2, it does not have toxic GI effects which are mediated through inhibition of COX-1.

SIDE EFFECTS
Sulfa Allergy
Sulfur-match Allergy-alligator

Celecoxib is a sulfonamide drug that can cause sulfa allergy.

Increased Risk of Thrombosis
Up-arrow Risk of Trombone

This is believed to occur due to COX-2 expression in vascular endothelial cells. Inhibition of COX-2 leads to decreased prostacyclin production and platelet aggregation.

GI Bleed
GI Bleeding

Celecoxib is much less likely than other NSAIDs to cause GI toxicity and bleeding, because it spares COX-1, which helps maintain the gastric mucosa. However, patients with a prior history of peptic ulcers still require precaution, becase gastrointestinal complications can still occur, especially when celecoxib is combined with aspirin.

CONTRAINDICATION
Pregnancy > 30 Weeks
Caution-tape Pregnant-woman with Greater-than Dirty-30

It is a category D drug after 30 weeks gestation and should not be prescribed.

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