Master Systemic Effects of Beta-Blockers with Picmonic for Medicine

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Cardiovascular Effects of Beta-Blockers

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2 mins

Nonselective Beta-Blockers

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2 mins

Epinephrine

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44 secs

Selective Beta-1 Blockers

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1 min

Calcium Channel Blockers (Verapamil and Diltiazem)

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2 mins

Systemic Effects of Beta-Blockers

Beta-fish with System Blocks

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Beta blockers have numerous systemic effects. β blockers such as timolol and betaxolol are used in the eye, as they reduce intraocular pressure by decreasing aqueous humor production. A respiratory side effect of beta blocker use is the possibility of causing bronchoconstriction. There are metabolic effects of beta blockers as well, such as decreasing insulin secretion by the pancreas. Furthermore, beta blockers decrease glycolysis and lipolysis, reducing blood glucose. Diabetic patients should be aware of their blood sugar, as beta blockers may mask the usual signs of hypoglycemia.

7 KEY FACTS

The lungs have beta 2 receptors and typically bronchodilate when adrenoreceptors are activated. However, when beta blocker drugs are used, bronchoconstriction occurs.

By blocking beta 2 adrenoreceptor activity, beta blocking medications lead to bronchoconstriction in patients. Typically, beta 2 adrenoreceptor activation leads to bronchodilation.

Adrenergic receptors influence the metabolic system; Beta 3 receptors lead to increased lipolysis, while Beta 2 activation leads to increased insulin release. Thus, beta blocking drugs work to decrease lipolysis and insulin release. In diabetic patients taking insulin, beta blockers block the usual symptoms of hypoglycemia and patients should be aware of their blood glucose.

By blocking beta 2 adrenergic receptors, beta blocking medications decrease insulin release from the pancreas.

Beta blockers block glycolysis (via decreased glucagon release) and decrease lipolysis. Furthermore, glycogenolysis is also decreased.

The ciliary epithelium contains beta adrenergic receptors and ligand binding (epinephrine and norepinephrine) stimulates the formation of aqueous humor. Thus beta blockers decrease aqueous humor formation.

Beta blockers such as timolol and betaxolol decrease aqueous humor formation by blocking beta adrenergic receptors on the ciliary bodies.

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