Master Hydralazine with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Hydralazine

Hydra-Laser
Picmonic
Hydralazine is a vasodilator that helps to relax smooth muscle and decrease peripheral resistance, helping to lower blood pressure and reduce afterload. This drug increases cyclic GMP levels, leading to smooth muscle relaxation, and ultimately, arteriodilation with a slight amount of venodilation. Thus, hydralazine directly relaxes arteriolar muscle to treat severe hypertension and CHF, and is often combined with methyldopa to treat hypertension in pregnancy. Side effects of hydralazine use include drug-induced lupus and up to 95% of patients with this affliction will display anti-histone antibodies. Furthermore, this medication can cause reflex tachycardia due to the drug's sudden pressor actions, and it is often co-administered with a β-blocker to prevent this.
8 KEY FACTS
INDICATIONS
Reduce Afterload
Down-arrow After-load Heart-pump

Hydralazine relaxes smooth muscle and preferentially vasodilates arterioles, creating an afterload reduction. It is indicated in diseases where there is cardiac failure or excess systemic resistance.

Severe Hypertension
Severed Hiker-BP

Hydralazine is used clinically to treat severe hypertension, however it is not indicated for essential hypertension. It is also a first-line treatment for hypertension during pregnancy (combined with methyldopa).

Safe during Pregnancy
Pregnant-lady inside Safe

Hydralazine is indicated for hypertension during pregnancy along with methlydopa.

CHF
CHF Heart-balloon

Along with severe hypertension, hydralazine can be used to treat CHF.

MECHANISM OF ACTION
Increases cGMP
Up-arrow cycle-GraMP

While the mechanism of action of hydralazine is not completely understood, it is thought to work by increasing cyclic GMP levels, which ultimately inhibits contraction in smooth muscle and leads to blood vessel relaxation.

Vasodilates Arterioles
Vase-dyed with Artery-O's

Increases in cyclic GMP levels and inhibition of smooth muscle contraction leads to greater vasodilation of arterioles than veins.

SIDE EFFECTS
Drug-induced Lupus
Loopy Pill-butterfly

Drug-induced lupus, an autoimmune response caused by chronic use of some drugs, may be seen as a side effect. Patients will likely display anti-histone antibodies.

Reflex Tachycardia
Reflex-hammer Tac-heart-card

Reflex tachycardia is a possible side effect, which occurs as a compensatory response to sudden decreased blood pressure to maintain cardiac output. Hydralazine is often coadministered with a beta-blocker to prevent this. Hydralazine is contraindicated in angina and CAD, and can cause angina.

Unlock all 8 facts & definitions with Picmonic Free!

JOIN FREE

Take the Hydralazine Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.