Master ACE Inhibitors with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

ACE Inhibitors

Ace with Inhibiting-chains
Picmonic
ACE inhibitors are antihypertensive drugs that work by inhibiting the renin-angiotensin-aldosterone-system. They help to lower blood pressure by inhibiting angiotensin-converting enzyme and decreasing the amount of angiotensin II and aldosterone. Effects of inhibiting this conversion are translated into lowered arteriolar resistance and increased venous capacity. This drug class decrease cardiac output and index, and stroke volume. Furthermore, natriuresis is increased, while there is decreased resistance in the blood vessels of the kidney.A side effect of these drugs is increased bradykinin, which may display as a persistent dry cough in patients.
9 KEY FACTS
-Pril Suffix
Pearls

ACE inhibitors share a "-pril" suffix, and include drugs like captopril, enalapril, and lisinopril.

INDICATIONS
Hypertension
Hiker-BP

These drugs were initially developed to treat hypertension, and can be used alone or in combination. It was later that they were found to be helpful in other renal and cardiovascular diseases.

CHF
CHF Heart-balloon

ACE inhibitors are indicated to treat CHF, when left ventricular systolic dysfunction exists. They can also be used in angina, cardiac ischemia, and post-MI patients.

Diabetic Nephropathy
Dyed-beads Kidney

ACE inhibitors are effective in treating diabetic nephropathy, caused by diabetes mellitus. Research has shown that ACE inhibitors are renal protective and slow the associated morphological changes in the glomeruli seen with renal disease.

MECHANISM OF ACTION
Inhibits ACE
Inhibiting-chains on Ace

ACE inhibitors inhibit angiotensin-converting enzyme, which is secreted by the lungs and kidneys. This inhibition prevents the formation of angiotensin II, thus preventing activation of AT-1 receptors in the adrenal cortex. Furthermore, this leads to lowered aldosterone levels.

Decreases GFR
Down-arrow Gopher

Angiotensin II maintains or even increases glomerular filtration rate (GFR) by preferentially constricting the efferent arteriole. ACE inhibitors prevent the formation of Angiotensin II. This causes relaxation of the efferent arteriole so GFR decreases. For this reason, ACE inhibitors are contraindicated in patients with bilateral renal artery stenosis as these patients already have a low GFR from low RBF.

Inhibits Constriction of Efferent Arteriole
Inhibiting-chains on Constrictor around E-fairy Artery

ACE inhibitors block efferent arteriolar constriction (normally caused by angiotensin II), thus decreasing GFR. It should be noted that there will be increased concentration of renin because of the negative feedback of angiotensin I to angiotensin II conversion.

SIDE EFFECT
Increased Bradykinin
Up-arrow Brady-crying

Inhibition of angiotensin converting enzyme leads to increased levels of bradykinin, which is a potent vasodilator and is associated with a dry cough.

Cough
Coughing Coffee-pot

A common adverse effect of ACE inhibitors is a persistent dry cough, often associated with the increases in the levels of bradykinin.

Unlock all 9 facts & definitions with Picmonic Free!

JOIN FREE

Take the ACE Inhibitors Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.