Master Aspirin with Picmonic for Medicine

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Aspirin

Aspirin
Picmonic
Also known as acetylsalicylic acid, aspirin is an anti-inflammatory, antipyretic, analgesic and antiplatelet drug. It is classified as an NSAID; however, its mechanism of action differs from other NSAID’s because it irreversibly inhibits COX-1 and COX-2 in comparison with other NSAID’s, which reversibly inhibit COX-1 and COX-2.
11 KEY FACTS
INDICATIONS
Fever
Fever-beaver

It is believed to reduce fever via blockage of Prostaglandin E2 (PGE2).

Pain and Headache
Pain-bolt and Head-egg-lump

It is believed to have pain-killing effects due to its inhibition of both COX-1 and COX-2.

Cardiovascular Disease (CAD)
Heart Diseased

Due to its antiplatelet effects, aspirin has been demonstrated to be effective for prevention of MI and ischemic stroke in those with existing cardiovascular disease (CVD) and those without CVD.

MECHANISM OF ACTION
Irreversible inhibition of COX-1 and COX-2
Locked Inhibiting-chains on Cock (1) Wand and Cock (2) Tutu

Aspirin irreversibly inhibit COX-1 and COX-2 and results in inhibition of production of prostaglandins (PG) and thromboxanes (TX).

Suppress Thromboxanes and Prostaglandins
Suppressing Trombone-axes and P-rasta

This prevents PGs from performing their role in inflammatory responses, pain processing and fever production and TXs from causing platelet aggregation.

NSAID
N-sad

Aspirin is classified as an NSAID but it performs irreversible, not reversible inhibition of COX-1 and COX-2.

SIDE EFFECTS
Reye's Syndrome
Rays from aspirin bottle

Administration of aspirin to children with viral infection is associated with microvesicular steatosis of hepatocytes, hepatoencephalopathy and potentially death. Causality has not yet been established.

Tinnitus
Tennis-ball-ringing-ear

Chronic aspirin toxicity can occur in individuals chronically taking 3g or more daily. This may result in ringing in the ears (tinnitus) possibly due to activation of cochlear NMDA receptors.

Peptic Ulceration
Gas Ulcer-volcano

PG’s produced by COX-1 help maintain the protective GI mucosal barrier in the stomach and intestines. Blockage of these PG’s via COX-1 inhibition can result in gastric ulcers.

Mixed Acidosis/Alkalosis
Acidic-lemon and Elk-loser

Aspirin toxicity can result in initial respiratory alkalosis due to hyperventilation and then metabolic acidosis. This presents as a mixed respiratory alkalosis and metabolic acidosis.

Nephropathy
Wavy-kidney

Aspirin can cause renal ischemia due to decreased renal blood flow, renal papillary necrosis or interstitial nephritis (acute or chronic).

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