Master Imipenem with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Imipenem

Emmy-penny
Picmonic
Imipenem is a beta lactamase resistant antibiotic with a broad spectrum of activity. It is a type of carbapenem that inhibits cell wall synthesis.  It is always administered intravenously with cilastatin, which is an inhibitor of renal dehydropeptidase I. Without cilastatin, imipenem is susceptible to degradation by renal dehydropeptidase I in the renal tubules. This wide spectrum antibiotic can be used for gram positives, gram negatives, aerobes and anaerobes. It is especially used for pseudomonas and enterococcus infections, but is not effective against methicillin resistant staphylococcus aureus (MRSA). Clinically, imipenem’s use is restricted to special cases to avoid development of bacterial resistance. This antibiotic also has many side effects such as nausea, vomiting, and seizures.Meropenem is another carbapenem with activity similar to imipenem but has reduced risk of seizures and does not require co-administration of cilastatin because it not degraded by dehydropeptidase I.
13 KEY FACTS
MECHANISM
Resistant to beta lactamases
Resisting (B lac) Black Beta-fish wearing Resistance-bandana

Carbapenem antibiotics like imipenem and meropenem are resistant to beta lactamases and can therefore cover a wide spectrum of bacterial infections.

Broad Spectrum
Broad Spectrum of Colors

Carbapenems like imipenem and meropenem cover a broad spectrum of bacteria such as gram positives, gram negatives, aerobes and anaerobes.

INDICATIONS
Anaerobes
Ant-robe

Anaerobic bacteria are bacteria that do not require oxygen for growth. This antibiotic can be used for anaerobic organisms.

Gram-Negative Rods
Graham-cracker Negative-devil with Rod

Gram negative rods are bacteria that stain gram negative due to relatively thin peptidoglycan layer in the cell wall with a rod shape. Imipenem covers a broad spectrum of bacteria including gram negative rods.

Gram-Positive Cocci
Graham-cracker Positive-angel with Cock-eyes

Gram positive cocci are gram positive organisms that absorb crystal violet on gram stain due to thick peptidoglycan layer with a spherical shape. Gram positive cocci include Staphyloccus and Streptococcus species. Imipenem covers a broad spectrum of bacteria including gram positive cocci.

Must administer with cilastatin
Silly-string

Imipenem can be degraded by renal dehydropeptidase I in the renal tubules and therefore requires co-administration with cilastatin, a dehydropeptidase I inhibitor. Meropenem, however, does not require cilastatin because it not degraded by dehydropeptidase I.

Cilastatin is inhibitor of renal dehydropeptidase I
Silly-string Inhibiting Kidney at Hydrant-pep-D

Cilastatin is always given together with imipenem to prevent imipenem's degradation by renal dehydropeptidase I.

SIDE EFFECTS
Diarrhea
Toilet

Carbapenems like imipenem and meropenem are known to cause GI distress including diarrhea, nausea and vomiting.

Skin rash
Skin Rash being examined by dermatolgoist

This is another occasional adverse effect caused by carbapenem antibiotics like imipenem and meropenem.

Seizures
Caesar

This is a more serious adverse effect that can occur with the use of imipenem. However, meropenem has a much reduced potential for this side effect compared to imipenem.

CONSIDERATIONS
Meropenem
Mirror-penny

Meropenem is another carbapenem with activity similar to imipenem but has reduced risk of seizures and does not require co-administration of cilastatin because it not degraded by dehydropeptidase I.

Stable to dehydropeptidase I
Unaffected by renal hydrant with Peptidase-logo

Meropenem, unlike imipenem, is stable to dehydropeptidase I and therefore does not require co-administration of cilastatin.

Reduced risk of seizures (Non seizure causing)
Nun Caesar

Meropenem has reduced risk of CNS toxicity or seizures as compared to imipenem.

Unlock all 13 facts & definitions with Picmonic Free!

JOIN FREE

Take the Imipenem Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.