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HIV Prophylaxis Medications (OLD VERSION)

AIDS bandaid cut by Purple-axes
Prophylaxis against opportunistic infection is treatment given to HIV-infected individuals to prevent either a first episode of an infection (primary prophylaxis) or the recurrence of infection (secondary prophylaxis). Prophylaxis is recommended to prevent three important opportunistic infections: Pneumocystis jiroveci pneumonia (PCP), Mycobacterium avium complex (MAC), and toxoplasmosis.
CD4+ < 200
CD (4) Fork with Less Than (200) Tooth-fairy

HIV patients with a CD4+ count below 200 should be treated to prevent the development of Pneumocystis jiroveci pneumonia (PCP). The proper prophylaxis for this is TMP-SMX.

Tampon on SMX-snowmobile

TMP-SMX (trimethoprim-sulfamethoxazole) is a combination drug used to help with prophylactic coverage in HIV patients. It is used in patients with CD4+ counts below 200 to prevent Pneumocystis jiroveci pneumonia (PCP), and in patients with CD4+ counts below 100 to prevent toxoplasmosis.

Pneumocystis pneumonia
Nude-Mona Sisters

Pneumocystis jiroveci pneumonia (PCP) is an opportunistic infection which affects HIV patients with CD4+ counts below 200.

CD4+ < 100 Susceptible to Toxoplasma gondii
CD (4) Fork with Less Than 100-dollar-bill at Tux-plasma Gandhi

At CD4+ counts below 100, patients are susceptible to opportunistic infection by toxoplasma gondii. Thus, when a patient's CD4+ count drops below 100, they are prophylactically given TMP-SMX.

CD4+ < 50
CD (4) Fork with Less Than 50 cent

In severely immunocompromised patients, a CD4+ level of below 50 they are susceptible to Mycobacterium avium complex (MAC). Prophylaxis for MAC is given in the form of Azithromycin.


Azithromycin is a macrolide antibiotic given to patients with a CD4+ of below 50, as they are susceptible to Mycobacterium avium complex.

Mycobacterium avium-intracellulare
Mic-bacteria Avian-birds Inside-cell

Mycobacterium avium complex (MAC), also known as Mycobacterium avium-intracellulare, is an opportunistic, AIDS-defining infection. Clinical manifestations include fever, weight loss, and night sweats in patients with CD4+ counts below 50. Prophylactic treatment is azithromycin.

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