Master Class IC Antiarrhythmics (Na+ Channel Blockers) with Picmonic for Medicine

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Class IC Antiarrhythmics (Na+ Channel Blockers)

(1) Wand C-Cat Ant-tie-arrhythmia-drummer (Salt Shaker Channel Blocked)
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Class IC antiarrhythmics treat severe ventricular tachyarrhythmias by blocking Na+ channels and slowing conduction. They have no effect on AP duration and are used as a last resort in refractory tachyarrhythmias, which may become intractable or progress to ventricular fibrillation. Drugs in this class include flecainide and propafenone, the latter of which acts as a β-adrenergic antagonist and has the side effects of bradycardia and CHF.

These drugs are contraindicated in patients immediately after myocardial infarctions and in patients with structural abnormalities due to their propensity to increase mortality in these groups.

6 KEY FACTS
INDICATIONS
Used as Last Resort
Last Resort sign

These drugs are used as a last resort in refractory tachyarrhythmias.

V-Tach
V-Tac

Class IC antiarrhythmic drugs are used in ventricular tachycardia (especially in intractable cases), which may progress to ventricular fibrillation.

MECHANISM OF ACTION
No Effect on AP Duration
Unharmed Action-clapper-P at AP Duration

Class IC antiarrhythmics have no effect on AP duration, as opposed to other Class I antiarrhythmics.

DRUGS
Propafenone
Pro-payphone

Propafenone treats rapid heart beat arrhythmias, such as supraventricular arrhythmias. It has a similar spectrum of action to quinidine and possesses β-adrenergic antagonist activity. It may also prevent life-threatening ventricular arrhythmias, but has side effects of CHF, bradycardia and new arrhythmias.

Flecainide
Flea-canine

Flecainide is a class IC antiarrhythmic drug indicated for ventricular tachyarrhythmias and for maintaining sinus rhythms in cases of paroxysmal atrial fibrillation or atrial flutter.

CONTRAINDICATIONS
Post-Myocardial Infarction
Post in Mayo-heart Infarction-fart

This class of drugs has proarrhythmic activity and are contraindicated post-MI and after structural heart disease due to increased mortality incidence with these diseases.

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