Master Zollinger-Ellison Syndrome Disease with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Zollinger-Ellison Syndrome Disease

Zoolander-Elephant with Mechanisms and Symptoms
Picmonic
Zollinger-Ellison syndrome (ZES) is caused by gastrin-secreting tumors, known as gastrinomas. The sequelae of this disease are the result of excess gastric acid production, which leads to abdominal pain, heartburn, diarrhea and ulcers in patients. These ulcers present most commonly in the proximal duodenum, and less commonly in the distal duodenum and jejunum. Furthermore, these are usually solitary ulcers. Patients may present with gastrointestinal bleeding as well. Abdominal pain and heartburn occur secondary to gastroesophageal reflux disease (GERD), which develops in roughly 50% of patients with Zollinger-Ellison syndrome. The gastrinomas of this disease can be sporadic and can occur without any other disease present. However, an important correlation of this disease is that 25% of cases are associated with multiple endocrine neoplasia type 1 (MEN 1).
7 KEY FACTS
PATHOPHYSIOLOGY
Gastrin-Secreting Tumor
Gas Secreting Tumor-guy

These gastrin-secreting tumors, or gastrinomas, are found in the pancreas or duodenum. These tumors arise from neuroendocrine cells, and their excessive production of the hormone gastrin leads to overproduction of gastric acid.

Increased Gastric Acid
Up-arrow Gas Acidic-lemon

Gastrinomas are neuroendocrine-derived tumors that secrete gastrin, leading to growth of gastric mucosa, and increased proliferation of stomach parietal cells. These cells proliferating cells produce an excess of gastric acid.

Recurrent Peptic Ulcers
Recurrent-clock on Pepper Ulcer-volcano

Due to excess acid production, recurrent ulcers occur in affected patients. These ulcers present most commonly in the proximal duodenum, and less commonly in the distal duodenum and jejunum. Furthermore, these are usually solitary ulcers. Patients may present with gastrointestinal bleeding as well.

MEN Type 1
Man with #1 Foam-finger

Zollinger-Ellison Syndrome (ZES) gastrinomas can be sporadic and can occur without any other disease. However, an important correlation of this disease is that 25% of cases are associated with multiple endocrine neoplasia type 1 (MEN 1).

SYMPTOMS
Abdominal Pain
Abdominal Pain-bolt

Patients with Zollinger-Ellison syndrome (ZES) commonly present with abdominal pain, which is a result of gastroesophageal reflux disease (GERD) or ulcerations from gastric acid hypersecretion.

Heartburn (Pyrosis)
Heart-burning

Heartburn is another common symptom seen in patients with Zollinger-Ellison syndrome (ZES). This occurs because of gastroesophageal reflux disease (GERD) that develops from gastric acid hypersecretion.

Diarrhea
Toilet

As a result of excess acid secretion and malabsorption, patients often complain of bouts of diarrhea, which is often seen as a chronic symptom of Zollinger-Ellison syndrome (ZES).

Unlock all 7 facts & definitions with Picmonic Free!

JOIN FREE

Take the Zollinger-Ellison Syndrome Disease Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.