Krukenberg Tumors are caused by metastasis to the ovaries from a separate primary location, and often present bilaterally.
Metastasis from a separate primary tumor to the ovaries often occurs through retrograde lymphatic spread.
Common primary tumor sources include metasases from gastric cancer and breast cancer.
Malignancy from the gastrointestinal tract, especially adenocarcinoma at the pylorus, is the most common cause.
Tumors can be identified microscopically through the presence of mucin-secreting signet cells in the ovarian tissue. Similar cells are typically found at the primary tumor as well.
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