Brenner tumors are rare, non-germ cell tumors of the surface epithelial-stromal type, which appear encapsulated and pale yellow-tan in color. Most tumors are benign and unilateral, and are histologically similar to transitional epithelium found in the bladder. On histology, the cells of Brenner tumors appear to have coffee-bean shaped nuclei.
Brenner tumors are non-germ cell tumors, appearing encapsulated and grossly pale, yellow-tan in color.
Histologically, Brenner tumor tissue appears similar to transitional-type epithelium with fibrous stroma, as seen in bladder tissue.
The vast majority of Brenner tumors are benign and unilateral. These tumors may vary greatly in size, ranging from 1 to 30 cm in presentation. These tumors are rarely malignant.
Brenner tumor cells have distinctive coffee-bean shaped nuclei, a description derived from the longitudinal nuclear grooves and fibrous stroma seen on histology.
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