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Lewy Bodies

Louis C.K.
Picmonic
Lewy bodies are abnormal eosinophilic protein aggregates which accumulate in nerve cells in degenerative disorders such as Parkinson's disease and Lewy body dementia. These aggregates are composed of α-synuclein, and can be accompanied by neurofibrillary tangles and Tau proteins.
4 KEY FACTS
PATHOPHYSIOLOGY
Alpha-synuclein Defect
Afro-Sneaker-lion Broken

α-synuclein is the main component of eosinophilic cytoplasmic inclusions, which are found in Lewy bodies. These are identified histologically in brain tissue.

Eosinophilic Cytoplasmic Inclusion
Eosinophilic-Eagle with Inkblots

Lewy bodies are eosinophilic cytoplasmic inclusions within nerve cells.

ASSOCIATED PATHOLOGIES
Parkinson's Disease
Park-in-sun Garage

Histologically, Lewy bodies are characteristic of Parkinson's disease, and are found in post-mortem examination.

Lewy Body Dementia
Louis C.K. Demented D-Man

Lewy body dementia is also associated with Lewy bodies. This disorder is described as an initial dementia with visual hallucinations, which is followed by parkinsonian features.

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