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Movement & Degenerative Disorders

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Lewy Bodies

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Lewy Bodies

Louis C.K.

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Lewy bodies are abnormal eosinophilic protein aggregates which accumulate in nerve cells in degenerative disorders such as Parkinson's disease and Lewy body dementia. These aggregates are composed of α-synuclein, and can be accompanied by neurofibrillary tangles and Tau proteins.

4 KEY FACTS

α-synuclein is the main component of eosinophilic cytoplasmic inclusions, which are found in Lewy bodies. These are identified histologically in brain tissue.

Lewy bodies are eosinophilic cytoplasmic inclusions within nerve cells.

Histologically, Lewy bodies are characteristic of Parkinson's disease, and are found in post-mortem examination.

Lewy body dementia is also associated with Lewy bodies. This disorder is described as an initial dementia with visual hallucinations, which is followed by parkinsonian features.

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