Master Kallman Syndrome with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Kallman Syndrome

Call-man
Picmonic
Kallman syndrome, or hypogonadotropic hypogonadism, is a genetic disorder leading to failure to start or complete puberty. This occurs because of defective migration of GnRH releasing-neurons to the hypothalamus, leading to hypogonadism. Patients display anosmia, delayed puberty and infertility.
6 KEY FACTS
Mutation in KAL-1 or FGFR-1 Gene
Mutant who Calls-1 for FroG-Firefighter-(1) Wand

Though most cases of this disorder have an unknown origin, there is evidence that FGFR-1 (fibroblast growth factor receptor 1) and KAL1 gene defects can lead to Kallman Syndrome. These genes help normal migration of GnRH neurons into the hypothalamus.

Failure of GnRH Secreting Neurons
Failure of Gonad-gopher Nerve Secretion

This syndrome occurs from defective migration of GnRH releasing neurons to the hypothalamus. This leads to decreased synthesis and release of GnRH in the hypothalamus, leading to decreased gonadotropin release.

Delayed Puberty
Delayed Pubescent-teen

Due to low serum testosterone and gonadotropins, LH and FSH, patients can show delayed puberty. This can also manifest as incomplete puberty, which is also a cause of hypogonadotropic hypogonadism.

Anosmia
Broken A-nose

Anosmia occurs because normal GnRH neurons originate in the olfacory placode, pass through the olfactory bulb to the hypothalamus. If there is a neuron migration issue, where this path is no longer taken, the patient's smell becomes defective because of olfactory bulb development issues.

Hypogonadism
Hippo-gonads

Due to improper migration of GnRH releasing cells, hypogonadism occurs. Patients have low levels of FSH, LH and resultingly, testosterone and estrogen.

Infertility
Infertile-plant

Due to hormone abnormalities, adult patients are often infertile. Males can show low sperm counts, while many females will present with amenorrhea.

Unlock all 6 facts & definitions with Picmonic Free!

JOIN FREE

Take the Kallman Syndrome Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.