Immunoglobulins are also known as antibodies and are rearranged during B cell development.
CD19 is expressed on B cells and acts as a co-receptor with CD21 and present on B cells at all levels but is lost if it undergoes transformation to a plasma cell.
CD20 is expressed on the cell surface of B cells. It is involved in optimizing immune responses. It is present on B cells after the Pro-B but is lost if transformation to a plasma cell occurs.
Also known as the Epstein-Barr receptor, CD21 is is expressed on the cell surface of B cells while acting as a co-receptor with CD19 to enhance Ag binding. It is present after the Pre-B stage until terminal differentiation into a plasma cell.
CD40 is a costimulatory molecule expressed by B cells which binds to CD40 ligands and is required immunoglobulin isotype switching, enhancing affinity of the immunoglobulin for specific antigens, and the formation of plasma and memory B cells.
Major histocompatibility complex II are part of the human leukocyte antigen (HLA) system (HLA-DP, HLA-DQ, HLA-DR) and are present on antigen presenting cells including B cells, macrophages and dendritic cells.
B7 is a protein involved in the activation of T cells.
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