Master Common Variable Immunodeficiency with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Common Variable Immunodeficiency

Common-Conan with Variable-vacuum
Picmonic
Common variable immunodeficiency consists of a group of approximately 150 primary immunodeficiencies which have a common set of features but variable underlying causes. Overall, there is a defect in B cell maturation, leading to decreased number of plasma cells, and decreased immunoglobulins of all classes, but normal number of B cells. Because the patient is not able to produce sufficient antibodies in response to exposure to pathogens, they are at increased risk of recurrent sinopulmonary infections. In addition to infections, individuals are also at increased risk of autoimmune diseases and cancer such as lymphomas. Diagnosis is usually made by demonstrating low levels of immunoglobulins in the serum.
6 KEY FACTS
PATHOPHYSIOLOGY
Defect in B Cell Maturation
Baby (B cells) Basketballs

Overall, common variable immunodeficiency is characterized by a defect in B cell maturation, leading to decreased number of plasma cells and low levels of immunoglobulins in the serum. The number of B cells is normal, however.

Decreased plasma cells
Down-arrows on histology of Plasma Cells

Overall, common variable immunodeficiency is characterized by a defect in B cell maturation, leading to decreased number of plasma cells and low levels of immunoglobulins in the serum. This leads to inadequate response to pathogens and recurrent infections.

Decreased immunoglobulins
Down-arrow In-moon-goblins

Overall, common variable immunodeficiency is characterized by a defect in B cell maturation, leading to decreased number of plasma cells and low levels of immunoglobulins in the serum. This leads to inadequate response to pathogens and recurrent infections.

SIGNS & SYMPTOMS
Sinopulmonary infections
Sinner-with-lungs

Because the patient is not able to produce sufficient antibodies in response to exposure to pathogens, they are at increased risk of recurrent sinopulmonary infections.

Increased Risk of Autoimmune Disease
Auto-in-moon

There is an increased risk of autoimmune diseases in patients with Common variable immunodeficiency, with a risk of up to 25%. Most commonly, autoimmune destruction of platelets or red blood cells is seen.

Lymphoma
Lime-foam

Common variable immunodeficiency may predispose individuals to developing lymphomas, although the exact mechanism is poorly understood.

Unlock all 6 facts & definitions with Picmonic Free!

JOIN FREE

Take the Common Variable Immunodeficiency Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.