Master Myotonic Dystrophy with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Myotonic Dystrophy

Muscle-tonic man with Disc-trophy
Picmonic
Myotonic dystrophy is a chronically progressive multisystem disease, which is inherited in an autosomal dominant fashion. The genetic origin results from trinucleotide repeats of CTG.  Myotonia, which is the continued involuntary contraction of a group of muscles, is the characteristic symptom in this disease. Patients often complain of muscle stiffness and have difficulty releasing their grip. Patients also commonly have cataracts, testicular atrophy, frontal balding and facial weakness. Lab findings can show conduction defects and muscle breakdown.  
10 KEY FACTS
PATHOPHYSIOLOGY
Autosomal Dominant
Domino

This disease is inherited in an autosomal dominant fashion.

Trinucleotide Repeat
DNA-strands with Repeats

Trinucleotide repeat inheritance results in the accumulation of CTG repeats, and worsening of the disease over generations.

CTG
Cans and Trophies with Gold

CTG is the trinucleotide repeat sequence. It is found on the DMPK gene, on the long arm of chromosome 19.

SIGNS AND SYMPTOMS
Facial Muscle Weakness
Weak and Drooping Facial Muscles

Atrophy of the muscles of the face is characteristic of myotonic dystrophy, often leading to ptosis and a typical facial appearance.

Frontal Balding
Frontal Baldness

Frontal balding is an additional finding in many of these patients.

Sustained Grip
Locked Grip

Sustained grip is one of the classic findings in myotonic dystrophy, and is caused by conduction defects and subsequent inability to inhibit the increased tone of grip.

Conduction Defects
Conduction-cables to Heart

Conduction defects can be found in patients with the disease due to nerve damage.

Cataracts
Cadillac-cataracts

Cataracts are the clouding of the lens in the eye that obstruct the passage of light. They are present in almost every patient and may be detected early in the course by slit-lamp examination.

Selective Atrophy of Type 1 Fibers
@-trophy with (1) Wand

Histochemical stains have demonstrated selective atrophy of type 1 fibers in patients. Type 1 fibers are slow-twitch and oxidative fibers that contain large amounts of myoglobin and mitochondria with many blood capillaries, giving the muscle a red appearance.

Testicular Atrophy
Testicle @-trophy

Testicular atrophy is a characteristic finding in myotonic dystrophy.

Unlock all 10 facts & definitions with Picmonic Free!

JOIN FREE

Take the Myotonic Dystrophy Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.