Master Nonbenzodiazepine Hypnotics with Picmonic for Medicine

With Picmonic, facts become pictures. We've taken what the science shows - image mnemonics work - but we've boosted the effectiveness by building and associating memorable characters, interesting audio stories, and built-in quizzing.

Nonbenzodiazepine Hypnotics

Nun-benz-dice Hypnotist
Picmonic

Nonbenzodiazepines hypnotics include Zolpidem (Ambien), zaleplon and eszopiclone, and are indicated for short term treatment of insomnia. This class of hypnotics is more selective than benzodiazepines, as they are not indicated for chronic anxiety, muscle relaxation, or seizure disorders. Nonbenzodiazepines hypnotics act on BZ1 GABA subtype receptors to increase chloride conductance. They are rapidly metabolized by the liver and have a short half-life of roughly 2.5 hours.

Patients taking these medications may display ataxia and confusion shortly after administration. Those who overdose on this class of medication can be treated with flumazenil as an antidote.

7 KEY FACTS
INDICATIONS
Insomnia
Taped-awake-insomniac

This class of drugs is effective in treating sleep disorders, such as insomnia. They show less risk for tolerance and dependance when compared to benzodiazepines.

MECHANISM OF ACTION
Short Half-Life
Shorts Half-Life-clock

This drug class works rapidly and has a short half-life due to quick metabolism by liver enzymes.

Acts on BZ1 GABA receptor
Bee-Z-(1) Wand GABA-goose receptor

These drugs work by acting via the BZ1 subtype of the GABA receptor, which increases chloride conductance. This is similar to the mechanism of action of benzodiazepines, but these two drug classes are not structurally similar.

Less dependence
Lifting away Dependence-ball-and-chain

Compared to benzodiazepines, nonbenzodiazepines have overall lower risk of dependence, tolerance and abuse. They cause less day-after psychomotor depression and amnestic effects relative to older sedative-hypnotics.

DRUGS
Zolpidem (Ambien)
Z-pigeon

Zolpidem is a commonly used drug of this class, and is also known as Ambien. Zolpidem helps to reduce sleep onset latency, and may also have some minimal anxiolytic activity. Other nonbenzodiazepine hypnotics are zaleplon and eszopiclone.

SIDE EFFECTS
Ataxia, confusion
A-taxi and Confucius

Patients may become impaired after taking this medication and may have trouble coordinating muscle movements and can appear to be very confused.

ANTIDOTE
Flumazenil for Overdose
Flute-mace-nail

Effects of this drug class can be blocked or reversed by flumazenil.

Unlock all 7 facts & definitions with Picmonic Free!

JOIN FREE

Take the Nonbenzodiazepine Hypnotics Quiz

Picmonic's rapid review multiple-choice quiz allows you to assess your knowledge.

START QUIZ NOW

It's worth every penny

Our Story Mnemonics Increase Mastery and Retention

Memorize facts with phonetic mnemonics

Unforgettable characters with concise but impactful videos (2-4 min each)

Ace Your Medical (MD/DO) Classes & Exams with Picmonic:

Over 870,000 students use Picmonic’s picture mnemonics to improve knowledge, retention, and exam performance.

Choose the #1 Medical (MD/DO) student study app.

Picmonic for Medicine (MD/DO) covers information that is relevant to your entire Medical (MD/DO) education. Whether you’re studying for your classes or getting ready to conquer the USMLE Step 1, USMLE Step 2 CK, COMLEX Level 1, or COMLEX Level 2, we’re here to help.

Works better than traditional Medical (MD/DO) flashcards.

Research shows that students who use Picmonic see a 331% improvement in memory retention and a 50% improvement in test scores.