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Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

Silver-Tonic and North-Epi-Pen Reuptake tube with Inhibiting-Chains
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Serotonin Norepinephrine reuptake inhibitors are a class of drug indicated for the use of major depression, diabetic peripheral neuropathy, panic and anxiety. Differing symptoms call for varied SNRI drug therapy. Duloxetine is a drug indicated for diabetic peripheral neuropathy, as well as depression. The drug venlafaxine is indicated to treat panic and anxiety disorders. SNRI drugs work by inhibiting reuptake of the neurotransmitters serotonin and norepinephrine, thus increasing their bioavailability, yielding increased neurotransmission. Side effects of these medications include hypertension and insomnia, which are thought to be associated with increased levels of norepinephrine. The most common side effect of SNRIs is nausea and vomiting, making this the primary reason for non-compliance with this therapy. Many patients complain of decreased libido and anorgasmia with SNRI treatment as well.
10 KEY FACTS
INDICATIONS
Depression
Depressed-emo

This drug is used for its antidepressant properties in patients with major depressive disorder.

Diabetic Peripheral Neuropathy
Dyed-bead-pancreas with Wavy-nerve-arms

The SNRI duloxetine is indicated for diabetic peripheral neuropathy and related neuropathic pain.

Duloxetine
Doll-ox

Duloxetine is used to treat peripheral diabetic neuropathic pain, and can also used for depression. Other indications for this drug include anxiety, chronic pain and fibromyagia. This drug has a greater effect on NE reuptake inhibition.

Panic and Anxiety
Panic-button and Anxiety-bag

Generalized panic and anxiety disorders are indications for use of the SNRI drug, Venlafaxine.

Venlafaxine
Vanilla-fax

Venlafaxine is a medication that works on serotonergic and noradrenergic receptors, when administered at moderate doses, to help treat anxiety and panic disorders.

MECHANISM OF ACTION
Inhibits Reuptake of Serotonin and NE
Inhibit-chains on Silver-tonic and North-epi-pen Reuptake-tube

The mechanism by which SNRIs work by inhibiting the reuptake of the neurotransmitters serotonin and norepinephrine. This leads to an increase in neurotransmission by increasing the availability of extracellular concentrations of serotonin and norepinephrine.

SIDE EFFECTS
Hypertension
Hiker-BP

Hypertension is a side effect of SNRIs, which is attributed to the increased circulating amounts of NE.

Insomnia
Taped-awake-insomniac

The side effect of SNRI associated insomnia is believed to be caused by increased circulating NE.

Nausea and Vomiting
Vomiting

Nausea and vomiting are typically the most common side effects related to SNRI therapy.

Decreased Libido
Down-arrow Libido-limbo

Patients commonly complain of decreased sexual desire (decreased libido), as well as an inability to reach sexual climax (anorgasmia).

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