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Heparin Indications

Indications

Acute Coronary Syndrome (ACS)

Heparin is most likely indicated for which of the following?

Prophylaxis

Which of the following describes the most appropriate use of heparin?

Pulmonary Embolism

Atrial Fibrillation

Used during Pregnancy

Which of the following is the most appropriate statement regarding heparin use?

Heparin Induced Thrombocytopenia (HIT)

Pathophysiology

5-10 Days After Heparin Exposure

Which of the following time frames is most likely associated with symptomatic heparin-induced thrombocytopenia (HIT)?

Heparin-Platelet Factor 4 Complex

In heparin-induced thrombocytopenia (HIT), autoantibodies are formed against which of the following?

Autoantibodies Form Against Complex

Which of the following mechanisms best explains the pathophysiology of heparin-induced thrombocytopenia (HIT)??

Heparin-Platelet Factor 4-Antibody Complex Binds Platelets

Platelet Aggregation

Regarding heparin-induced thrombocytopenia, heparin-platelet factor 4-antibody complex bound to platelets results in:

Procoagulant Release

Regarding heparin-induced thrombocytopenia, which of the following phenomena is most likely to be seen after the binding of platelets to heparin-platelet factor 4-antibody complex?

Symptoms

Thrombocytopenia

Which of the following is most likely to be seen in patients with heparin-induced thrombocytopenia (HIT)?

Diagnosis

Serotonin Release Assay (SRA)

What is the best diagnostic test for heparin-induced thrombocytopenia (HIT)?

Treatment

Stop Heparin, Start Direct Thrombin Inhibitor

Which of the following is the best intervention for heparin-induced thrombocytopenia (HIT)?

Heparin Mechanisms

Mechanism of Action

Short Half-life

Which of the following medication administration details are best associated with Heparin?

Antithrombin Activation Cofactor

What mechanism of action or pharmacological action is best associated with Heparin?

Decrease Thrombin, Factor Xa

Side Effects

Bleeding

During your assessment of a patient taking Heparin which of the following side effects is most likely to be seen?

Antidote

Protamine Sulfate

Which of the following medications is most likely the reversal agent or antidote used with Heparin?

Von Willebrand Disease

Mixed platelet and coagulation disorder

Which best describes the pathophysiology of Von Willebrand disease?

Mechanism

Autosomal Dominant Condition Leading to Reduced vWF

What is the most common mode of inheritance for Von Willebrand disease?

Defect in platelet plug formation

Labs

Increased Bleeding Time

Of the following, which is most likely attributed to a patient with Von Willebrand disease?

PTT increased

Factor VIII decreased

Normal platelet count

DDAVP (synthetic vasopressin)

Which of the following medications is most commonly used to treat Von Willebrand disease via its effects on factor VIII release?

Warfarin

Interferes with Vitamin K-dependent Clotting Factors

Which of the following best describes the mechanism of action of warfarin?

Extrinsic Pathway

Which of the following coagulation pathways provides information on warfarin's usefulness?

Bridge with Heparin

Which of the following is an important consideration when administering warfarin?

Chronic Anticoagulation

Which of the following is the most common indication for the use of warfarin?

Which of the following side effects is most likely to be seen in patients taking warfarin long-term?

Necrosis

Cytochrome P450

Warfarin is metabolized through which of the following pathways?

Contraindications

Pregnancy

Which of the following is a contraindication for the use of warfarin?

FFP + Vitamin K

Which of the following medications is used as a reversal agent for warfarin?

Warfarin Antidotes

Vitamin K

Which of the following is a treatment for Warfarin Toxicity?

Fresh Frozen Plasma

Antidotes

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