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Medicine (MD/DO)
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USMLE Step 1
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Pathology
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Other Hematologic Pathology

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Pathology | Medicine (MD/DO) School Study Aid

Other Hematologic Pathology
8 Picmonics to Learn | 22 mins
Primary Myelofibrosis
Characteristics
Bone Marrow Fibrosis
Extramedullary Hematopoiesis
JAK2 Kinase Mutation
Symptoms
Fatigue
Weight Loss
Splenomegaly
DIagnosis
Pancytopenia
Dacrocytes (Teardrop Cells)
Dry Tap on Bone Marrow Aspiration
Treatment
Stem Cell Transplantation
Transfusion
Ruxolitinib (JAK2 Inhibitor)
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2 mins
Tumor Lysis Syndrome
Characteristics
Leukemia/Lymphoma Treatment
Oncologic Emergency
Clinical Features
GI Distress
Fatigue
Arrhythmias
Acute Kidney Injury
Lab Findings
Hyperkalemia
Hyperphosphatemia
Hyperuricemia
Hypocalcemia
Management
Aggressive Hydration
Electrolyte Correction
Allopurinol
Rasburicase
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3 mins
Snake Bite Injury
Local Findings
Edema
Erythema
Tissue Necrosis
Systemic Findings
Neurotoxicity
Distributive Shock
Disseminated Intravascular Coagulation (DIC)
Diagnosis
Diagnosis by Clinical Impression
Management
Antivenom
Closely Monitor Patient
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2 mins
Langerhans Cell Histiocytosis
Characteristics
Antigen Presentation Defect
Lytic Bone Lesions
Skull
Presentation
Hypopituitarism
Diabetes Insipidus
Skin Rash
Recurrent Otitis Media
Diagnosis
Birbeck Granules
"Tennis Racket" Appearance
S100 Positive
Management
Observation
Prednisone +/- Vinblastine
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4 mins
Hemophagocytic Lymphohistiocytosis
Characteristics
Excessive Immune System Activation
Cytotoxic T-cells and Macrophages
Cytokine Storm
Acquired or Sporadic
Presentation
Fever
Hepatosplenomegaly
Labs
Increased Ferritin
Pancytopenia
Management
Bone Marrow Transplantation
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3 mins
Essential Thrombocythemia
Characteristics
JAK2 Mutation
Presentation
Often Asymptomatic
Thromboembolic Events
Spontaneous Abortion
Erythromelalgia
Gout
Diagnosis
Thrombocytosis
Megakaryocyte Hyperplasia
Management
Aspirin
Hydroxyurea
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2 mins
Myelodysplastic Syndromes
Characteristics
Dysfunctional Bone Marrow
Elderly
Radiation or Chemotherapy
Presentation
Anemia
Increased Susceptibility to Infection
Bleeding
Diagnosis
Ringed Sideroblasts
Howell-Jolly Bodies
Pseudo-Pelger-Huet Anomaly
Bilobed Neutrophils
Management
Supportive Care
Bone Marrow Transplant
Considerations
Acute Myelogenous Leukemia (AML)
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4 mins
Methemoglobinemia Characteristics
Characteristics
Oxidized Iron in Hemoglobin
Decreased Affinity for Oxygen
Increased Affinity for Cyanide
Etiologies
Dietary Nitrates
Drugs
Nitroglycerin
Lidocaine
G6PD Deficiency
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2 mins

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