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Medicine (MD/DO)
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USMLE Step 1
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Biochemistry
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Fundamentals of Metabolism

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Biochemistry | Medicine (MD/DO) School Study Aid

Fundamentals of Metabolism
8 Picmonics to Learn | 14 mins
Aerobic Respiration
Mitochondrial Matrix
2 Pyruvate
Pyruvate Decarboxylation
2 NADH
2 Acetyl-CoA
Krebs Cycle
6 NADH
2 FADH2
2 Substrate Level ATPs
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1 min
Anaerobic Respiration
Cytosol
Glucose
Glycolysis
Substrate-level Phosphorylation
2 NADH
2 Net ATP
2 Pyruvate
Fermentation
NAD+ Regeneration
Waste Byproduct
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2 mins
Oxidative Phosphorylation
Inner Mitochondrial Membrane
Electron Transport Chain
Oxygen is Final Electron Acceptor
Proton Pump
Proton Motive Force
ATP Synthase
1 NADH 3 ATP
1 FADH2 2 ATP
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2 mins
Energy Releasing Pathways: Accounting
Characteristics
Anaerobic Respiration
2 ATP
2 NADH
Aerobic Respiration
8 NADH
2 FADH2
2 ATP
Oxidative Phosphorylation
34 ATP
2 ATP Lost
36 Net Total ATP
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2 mins
Enzyme Types
Characteristics
Lyases
Hydrolases
Transferases
Isomerases
Oxidoreductases
Ligases
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1 min
Competitive Inhibition
Reversible Inhibition
Constant Vmax
Substrate Competes With Inhibitor For The Active Site
Inhibition Increases Km
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1 min
Non-Competitive Inhibition
Characteristics
Reversible Inhibition
Substrate Freely Binds The Active Site
Inhibitor Strongly Binds Allosteric Site
Km Constant
Enzyme Has Different Conformational Form
Low Vmax
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2 mins
Lipoprotein Functions
Chylomicron
Carries Dietary TGs to Peripheral Tissues
VLDL
Carries Hepatic TGs to Peripheral Tissue
IDL
Carries TGs and Cholesterol to Liver
LDL
Carries Hepatic Cholesterol to Peripheral Tissues
HDL
Returns Excess Cholesterol from Peripheral Tissues to Liver
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2 mins

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