Chronic Lymphocytic Leukemia (CLL)
- Age > 60 Years
- B Cell Neoplasm
- Smudge Cells
- Often Asymptomatic
- Cold IgM Autoimmune Hemolytic Anemia
- Warm IgG Autoimmune Hemolytic Anemia
- Richter's Transformation
Acute Myelogenous Leukemia (AML)
- Myeloblasts Increase on Peripheral Smear
- Median Onset 60 Years
- T 15;17 M3 Subtype
- Auer Rods
- Disseminated Intravascular Coagulation (DIC) is a Common Presentation
- M5 Gum Infiltration
- Responds to Vitamin A
Chronic Myelogenous Leukemia (CML)
- BCR-ABL
- 9;22 Translocation
- Philadelphia Chromosome
- Tyrosine Kinase
- Low Alkaline Phosphatase
- Splenomegaly
- Blast Crisis
- Age 30 to 90 Years
- Responds to Imatinib