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Multiple Sclerosis Features and Mechanisms

(MS) Multiple Skull-roses with Features and Mechanisms
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MS is most common in young, white women. It has genetic and environmental components and is an autoimmune disease mediated by T-Cell inflammation.
8 KEY FACTS
FEATURES
Twice as often in Women
Two women

MS is more common in women than men, at a 2:1 ratio.

Presents in 20's and 30's
(20) Twenty dollar bill and (30) Dirty

Individuals with MS most often present in their 20s and 30s.

Northern Europeans
North-compass Europeans

MS is most common in individuals of Northern European descent.

MECHANISM
Unknown mechanism, genetic factor
Question-mark Mechanism with DNA-double-helix

The mechanism for autoimmune demyelination is not completely understood; however, there is a genetic factor in addition to environmental.

HLA-DRB1
HuLA Dr. with (B) Bee and (1) Wand

There is an association with the HLA-DRB1 haplotype and MS.

Autoimmune Demyelination of CNS
Auto-in-moon Demyelinating CNS-brain

It is believed that T-Cells react against self myelin antigens leading to recruitment of macrophages and leukocytes. This causes demyelination of the CNS.

White Matter of Brain and Spinal Cord
White Brain and Spinal Cord

White matter of the brain and spinal cord are particularly impacted, as white matter is composed chiefly of long-range myelinated axon tracts.

T Cell Mediated Inflammation
Tennis-ball spreading Flames

It is believed that T-Cells attack self myelin, recruiting macrophages and leukocytes. Thus, it is hypothesized that T-Cells are likely responsible for autoimmune inflammation reactions in MS.

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