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Primary Sclerosing Cholangitis Mechanisms

Mechanism

Unknown Mechanism

What best describes the pathophysiology of primary sclerosing cholangitis?

"Onion Skin" Fibrosis

Which of the following features is most commonly seen in primary sclerosing cholangitis?

"Beading" of Bile Ducts

Symptoms

Pruritus

Which of the following clinical features is typically seen in primary sclerosing cholangitis?

Hepatosplenomegaly

Jaundice

Primary Sclerosing Cholangitis Labs and Treatment

Labs

Increased Conjugated Bilirubin

Which of the following lab results should be expected in a patient with primary sclerosing cholangitis?

Increased ALK-P

Increased IgM

Associated Pathologies

Ulcerative Colitis

Which of the following pathologies is most closely related to primary sclerosing cholangitis?

Cholangiocarcinoma

Secondary Biliary Cirrhosis

Which of the following pathologies can result from the damage related to primary sclerosing cholangitis?

Treatment

Liver Transplant

Which of the following is considered the only definitive treatment of primary sclerosing cholangitis?

Stent

Which of the following is indicated for short-term symptomatic relief of primary sclerosing cholangitis?

Reye's Syndrome

Cause

Aspirin (Salicylates) to Treat Viral Illness (In Children)

Which of the following is most likely to cause Reye's syndrome?

Assessment

Cerebral Edema 

Which of the following signs may be seen in patients with Reye's syndrome?

Lethargy (Decreased LOC)

Vomiting

Liver Failure

Interventions

Monitor for Increased ICP

Which of the following is most important regarding interventions & monitoring during Reye's syndrome?

Mannitol (Osmitrol)

Which of the following medications is most likely used to treat cerebral edema associated with Reye's syndrome?

Considerations

No Aspirin for Children

Which of the following patient education points is important to prevent Reye's syndrome?

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