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Clostridium difficile, recently renamed Clostridioides difficile by the CDC, is a condition that causes inflammation of the colon. C. diff treatments are varied and depend both on disease severity and whether the disease is recurrent or not. You can recall them with this Picmonic about various students trying to defeat the classroom of differential equations with their vehicles. Oral vancomycin, the oral van-tank-mice responding, is a common choice for the initial treatment of C. difficile infection. Of note, it must be administered orally, because the intravenous form will not reach high enough levels in the GI tract. Vancomycin is also an option for both recurrent and severe infections. Fidaxomicin, the Fed Ex mice, is another antibiotic effective against C. diff. It can be used for initial or recurrent disease, and is more effective than metronidazole. One downside, however, is that this antibiotic is expensive. Metronidazole, the metro-knight, is another option for treating C. diff, although it is less effective than the other antibiotics. It can be used intravenously for severe disease, and is still used first-line in many parts of the world due to its affordability. For patients with persistent Clostridium difficile infection refractory to multiple courses of antibiotics, a stool transplant or fecal microbiota transplant can be considered, shown by the stool train-plant. This procedure instills healthy donor stool into the patient’s GI tract which replenishes the normal gut microbiome, and can help treat persistent C. diff colonization. So in summary, C. diff infection can be treated in multiple ways. Oral vancomycin is effective for initial, recurrent, and severe disease. Fidaxomicin is also effective, but is an expensive medication. Metronidazole is the least effective but is still used for severe disease and first-line in many parts of the world. A stool transplant or fecal microbiota transplant can be considered for patients with persistent infection refractory to multiple rounds of treatment.

educational

story

classroom differential equation.png

clostridium difficile treatments.png

Classroom Differential-equations

Clostridium difficile (Clostridioides difficile) Treatments

Clostridia

Clostridium difficile (Pseudomembranous colitis)

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Metro-knight

Metronidazole

Which of the following is most likely considered the treatment of choice for C. difficile associated diarrhea when first line agents are unavailable/too expensive?

oral van tank mice responding.png

Oral Van-tank-mice Responding

Oral Vancomycin

Which of the following medications is most likely indicated in the treatment of refractory cases of C. difficile associated diarrhea?

stool train plant.png

poop.png

Stool Train-plant

Stool Transplant

Which of the following is most likely indicated for the treatment of C. difficile associated diarrhea?

fed ex mice.png

Fed-Ex-mice

Fidaxomicin

Which of the following medications is most likely indicated in the treatment of C. difficile and belongs to the macrolide class of antibiotics?

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Potter, Perry, Stockert & Hall, 2017, Fundamentals of Nursing, 9th Ed.

We updated this Picmonic to include Fidaxomicin as a treatment.

This Picmonic is about C. diff treatments, represented by the classroom with differential-equations, and in tonight's class, we have a train, van, a Fedex truck and metro subway. First to speak up in class with their BIG MOUTHS is the oral van-tank mice. They respond to everything! But they aren't the only mice in class. The Fed-ex mice are in attendance and they are ready to deliver some answers! As well as packages, I guess. But not if the metro-knight has anything to do with it. He wants to ride in like a knight in shining armor and take down the classroom. But ultimately the one kid in class to defeat the differential-equation is the smelly kid. That’s right, the stool train-plants. Bleh!&nbsp;

Picmonic uses mnemonics to help you develop NCLEX mastery so you can pass the NCLEX exam the first time. Free question for 08/2022/04

Picmonic NCLEX Question of the Day 08/04/2022

Picmonic NCLEX® Question of the Day

You hear your colleague at the hospital say, "Whew! Nothing like the smell of C.difficile!" The nurse knows which of the following will most likely be administered for this infection?

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